うつ病・気分症群

単極性うつ病・双極症を含む気分症群の疫学。受療率の経年変化と国際比較。

本ページの概要

本ページは「うつ病・気分症群」について、患者調査・制度・文献・可視化リソースを統合してご紹介します。 内容は月次の自動更新で随時追記されます。

患者調査（時系列）

出典: 厚生労働省 患者調査

年 総患者数_千人 うつ病等_千人 双極性障害_千人 入院患者数_千人 外来患者数_千人 出典
1999 441.0 298.0 71.0 96.0 345.0 患者調査
2002 714.0 491.0 109.0 102.0 612.0 患者調査
2005 922.0 637.0 138.0 105.0 817.0 患者調査
2008 1040.0 728.0 161.0 106.0 934.0 患者調査
2011 958.0 670.0 148.0 98.0 860.0 患者調査（東日本大震災影響で一時減）
2014 1116.0 788.0 166.0 100.0 1016.0 患者調査
2017 1276.0 933.0 185.0 97.0 1179.0 患者調査
2020 1722.0 1275.0 217.0 95.0 1627.0 患者調査（コロナ禍急増）
2023 2000.0 1490.0 252.0 94.0 1906.0 患者調査（推計）

国際比較

出典: OECD Health Statistics ほか

国 12ヶ月有病率(%) 生涯有病率(%) うつ病入院率_人口10万人あたり 抗うつ薬処方率(%) 出典
日本 2.2 6.7 14.0 9.5 川上ら2006・患者調査2020
アメリカ 8.3 17.1 35.0 18.4 NSDUH2020
ドイツ 5.6 13.0 — 13.5 ESEMeD
フランス 4.7 10.0 — 18.2 ESEMeD
イギリス 5.0 12.0 — 16.5 NHS2021
韓国 2.5 5.7 — — KNHANES2020
世界平均 4.4 — — — WHO GBD2019

制度変遷メモ

うつ病・気分症群 診療体制・政策変遷メモ

主要制度転換点

1999年 — パキシル（パロキセチン）承認

  • 日本初のSSRI（選択的セロトニン再取込み阻害薬）承認
  • うつ病の診断・治療が急速に普及
  • 患者数は1999年→2002年でほぼ倍増（44万→71万人）

2000年代前半 — 「うつは心の風邪」キャンペーン

  • 製薬会社主導のメディア啓発
  • 受診行動の大幅な変化（中等・軽症うつの受診増）
  • 診断の裾野が拡大（DSM-IV基準の普及）

2006年 — ジェイゾロフト（セルトラリン）等の追加承認

  • 複数のSSRI/SNRIが競合参入
  • うつ病治療薬市場が急拡大

2009〜2010年 — 産業メンタルヘルス対策強化

  • 自殺対策基本法（2006）→自殺総合対策大綱（2007）
  • メンタルヘルス不調による休職者増加への対応
  • 復職支援プログラム（リワーク）の普及

2011年 — 東日本大震災

  • 被災地でのPTSD・うつ病急増
  • こころのケアチーム派遣（DPAT前身）
  • 一時的に患者数統計が乱れ（2011年調査：前回比減）

2014〜 — ストレスチェック義務化検討→施行（2015年）

  • 50人以上事業所でストレスチェック義務化
  • 職域でのうつ病早期発見・予防体制の整備

2015年 — レクサプロ（エスシタロプラム）普及

  • 忍容性が高く汎用的なSSRIとして広がる
  • 軽症うつへの投与が一般化

2020〜 — COVID-19パンデミック

  • 患者数が2020年で前回比35%以上増加
  • 孤独・孤立、失業、学業困難によるうつ病急増
  • オンライン診療の普及でアクセスが改善

2023〜 — 現在

  • 外来患者数200万人超（推計）
  • 「隠れうつ」「マイクロうつ」等の概念の普及
  • 精神科・心療内科の需要逼迫、予約待ち延長

診療体制上の課題

課題 状況
過少診断 vs 過剰診断 12ヶ月有病率の低さ（2.2%）と患者数急増の乖離
精神科・心療内科の過負荷 外来待機延長、1診療あたり時間が短縮
休職・復職支援 リワークプログラムの保険適用外、企業格差
自殺との関連 うつ病は自殺の最大危険因子（自殺者の60-90%にうつ）
薬物療法偏重 認知行動療法等の心理療法は提供体制が不十分

関連文献

出典: PubMed 等。最新登録順。 全 55 件中、最新 15 件を表示しています。

  1. Pradubkham T, Sukket T, Pimcharee S, Wichaiyo K, Phimarn W. Prevalence of Internet Addiction Among Thai Pharmacy Students: A Cross-Sectional Study. International journal of environmental research and public health (2026). PMID: 42074438 DOI
  2. Li J, Wu J, Huang Y, Zhuang Y. Prevalence and Associated Factors of Anxiety and Depression Among Primary Caregivers of Children With Haematological Malignancies: A Cross-sectional Study. Actas espanolas de psiquiatria (2026). PMID: 42023441 DOI
  3. Qing H, Ye L. Prevalence and Influencing Factors of Anxiety and Depression in Patients With Breast Cancer: A Meta-Analysis. Actas espanolas de psiquiatria (2026). PMID: 42023446 DOI
  4. Nguyen HP, Nguyen TTP, Nguyen NQ, Van Bui T, Le HA, et al. Prevalence of depression, anxiety and stress and associated workplace stressors among healthcare workers in a tertiary hospital in Vietnam: A cross-sectional study. PloS one (2026). PMID: 42008457 DOI
  5. Cheng R, Zhu W, Jiang S, Yang Z. Subthreshold depression prevalence and influencing factors among nursing students in vocational schools: A cross-sectional study. PloS one (2026). PMID: 42008490 DOI
  6. Tshomo T, Wongnuch P, Srichan P. Prevalence of and factors associated with depressive symptoms among the working population in Thimphu, Bhutan: A cross-sectional study. PloS one (2026). PMID: 42013137 DOI
  7. Hine BA, Harman JJ, Leder-Elder S, Bates EA. Prevalence and impact of parental alienating behaviors (PABs) in adults aged 18-25 in the United Kingdom. Frontiers in public health (2026). PMID: 42110299 DOI
  8. Tong L, Fan J, Wang X. Incidence of anxiety and depression in epilepsy patients and its correlation with disease control: A retrospective study. Medicine (2026). PMID: 42071840 DOI
  9. Necho M, Shegaw M, Anbesaw T, Birru N, Ayano G, et al. Prevalence of perinatal depression in Ethiopia: An umbrella review of systematic review and meta-analysis studies. PloS one (2026). PMID: 42044134 DOI
  10. de Araujo Lima D, de Paiva VA, de Souza Ribeiro AL, Zamboti CL. Sleep quality in pregnant women with lumbopelvic pain: prevalence of clinically significant sleep disturbance and comparison in clinical outcomes between pregnant women with and without clinically significant sleep disturbance. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine (2026). PMID: 42045728 DOI
  11. Ferreira RJDS, Monteiro CN, Dias DA, Rosa MRDD, Mondelli MFCG. Prevalence and characterization of tinnitus in patients with mental disorders in the context of primary health care. CoDAS (2026). PMID: 42054186 DOI
  12. Thapa K, Bhusal R, Mishra DKK, Shakya P. Prevalence and correlates of anxiety and depression among LGBT individuals in Nepal: a cross-sectional study. BMJ open (2026). PMID: 42049292 DOI
  13. Bojorquez I, Ibarra-González I, Pérez-Duperou G, Hernández C. Prevalence and Associated Factors of Mental Health Problems Among Internally Displaced Persons In-Transit in Mexico. The International journal of social psychiatry (2026). PMID: 41054324 DOI
  14. Gui Z, Chen P, Sha S, Zhang L, Su Z, et al. Gender Differences in Depression Prevalence, Influencing Factors, Life Satisfaction, and Network Structure Among Middle-Aged and Older Adults in China: A National Survey. The International journal of social psychiatry (2026). PMID: 41104581 DOI
  15. Braciszewski JM, Elmali M, Llamocca EN, Vanderziel AM, Cameron-Carter H, Loree AM. Prevalence and Mental Health Correlates of Electronic Cigarette Use Among Pediatric Primary Care Patients. Clinical pediatrics (2026). PMID: 41461569 DOI
過去の文献 40 件を表示
  1. Beckodro CK, Nsitou B, Edwards Q, Asifat O, Sullivan KL, Cowan LT. Electronic cigarette use and postpartum depression prevalence: The pregnancy risk assessment monitoring system (PRAMS). Journal of affective disorders (2026). PMID: 41506386 DOI
  2. Lehmann G, Ehrmann D, Olesen B, Priesterroth LS, Kulzer B, et al. Uncovering distinct predictors of diabetes distress and depressive symptoms in a longitudinal survival analysis of incidence and remission: indication for diverging aetiological paths. Diabetologia (2026). PMID: 41572009 DOI
  3. Cénat JM, Farahi SMMM, Dalexis RD, Jean L, Lafleur N, et al. Severe depression among Haiti's internally displaced populations: Prevalence and correlates in the context of gang violence. Psychiatry research (2026). PMID: 41687330 DOI
  4. Xu T, Chen Y, Shen Q, Dai S, Yan H, Ren J. A systematic review and meta-analysis of anxiety and depression in children and adolescents with inflammatory bowel disease: Prevalence and association. Journal of psychiatric research (2026). PMID: 41687568 DOI
  5. Thiele T, Ahrenstorf G, Witte T, Kahl KG, Hirsch S. Prevalence and recognition gap of depressive and anxiety symptoms in patients with inflammatory-rheumatic diseases - a single center experience. Journal of psychiatric research (2026). PMID: 41719638 DOI
  6. Liu X, Xu A, Zhu Y, Pan Q, Wang H, Zhang G. Prevalence and risk factors associated with anxiety and depression in patients with acute ischemic stroke who receive mechanical thrombectomy. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2026). PMID: 41831582 DOI
  7. Pavlović Z, Stevanović M, Krstić A, Ivković I, Vujčić M, et al. Vitamin D Deficiency in Bipolar Disorder: Prevalence, Sociodemographic and Clinical Characteristics. Human psychopharmacology (2026). PMID: 42063248 DOI
  8. Lu J, Li K, Wu S, Feng H, Dong Z, Zheng Z. The impact of different combinations of body mass index and depressive status on the incidence of sarcopenia in middle-aged and older adults ≥45 years: A retrospective cohort study based on CHARLS follow-up data from 2011 to 2015. Medicine (2026). PMID: 42116348 DOI
  9. Wang F, Lai X, Zhou S, Lin J, Xin H, et al. Olanzapine-Associated Hepatotoxicity in Bipolar Disorder: A Multicenter Real-World Study of Prevalence, Risk Factors, and Outcomes. Drug design, development and therapy (2026). PMID: 42130898 DOI
  10. Romeu D, Jadhakhan F, Taylor AK, Lindner OC, Blakemore A, Guthrie E. Prevalence of anxiety and depression in adults who are high users of healthcare services and magnitude of associated costs: a systematic review. BMJ open (2026). PMID: 42128508 DOI
  11. Shin D, Ham BJ, Kim KH. Affective morbidity after cancer diagnosis: Nationwide incidence and pharmacotherapy patterns across five major cancer types. Journal of affective disorders (2026). PMID: 41619608 DOI
  12. Mirchandani S, Tan MP, Morgan K. Prevalence and Characteristics of Depression, Anxiety and Stress Among Older Persons in Malaysia during the COVID-19 Pandemic. Journal of cross-cultural gerontology (2026). PMID: 42144482 DOI
  13. Liao T, Gan Y, Liu L, Tang M, Gan L, Li G. Prevalence and Associated Factors of Frailty in Middle-Aged and Elderly Patients with Atrial Fibrillation: An Exploratory Machine Learning Analysis. Clinical interventions in aging (2026). PMID: 42179963 DOI
  14. Sarkar AA, Alam MF, Ahmed HU, Alam MT, Khan NM. Prevalence, symptom profile, associated factors, and treatment gap of depressive disorders among adults: Findings from a nationwide household survey in Bangladesh. Journal of affective disorders (2026). PMID: 41672149 DOI
  15. Verbist IL, Lorimer B. Physical long-term conditions and psychological treatment outcomes in NHS Talking Therapies: Prevalence, impact, and moderators. The British journal of clinical psychology (2026). PMID: 41673545 DOI
  16. Smith M, Koons NJ, Callihan P, Guo N, Simard JF, et al. Prevalence of and Risk Factors for Postpartum Anxiety in a U.S. Cohort With Commercial Insurance. Obstetrics and gynecology (2026). PMID: 41747270 DOI
  17. de Aguiar KR, Zimmer C, Kampmann L, Caobelli ACSL, Chagas V, et al. Prevalence and clinical correlates of cocaine use disorder among patients diagnosed with bipolar disorder: A systematic review, meta-analysis, and meta-regression. Neuroscience and biobehavioral reviews (2026). PMID: 41833851 DOI
  18. Feng S, Liu L, Xiao G, Zhang Y, Zhou M, et al. Reassessing the burden of perinatal depression: A systematic review and meta-analysis on the prevalence and risk factors of perinatal depressive symptom trajectories. Midwifery (2026). PMID: 41856019 DOI
  19. Hadj-Youssef S, Civita A, Chartrand E, Malboeuf-Hurtubise C, Fuoco J, et al. Prevalence and mental health correlates of non-suicidal self-injury in elementary school children. Psychiatry research (2026). PMID: 41865642 DOI
  20. Halstead S, Arnautovska U, Kisely S, Siskind D, Warren N. Comparative incidence rates of physical multimorbidity in a psychiatric inpatient population among people with and without severe mental illness: A retrospective cohort study. The Australian and New Zealand journal of psychiatry (2026). PMID: 41877559 DOI
  21. Zhou L, Guan M, Zhang B, Zhao C, Sun Z, et al. Depression in Parkinson's disease: prevalence and impact on oculomotor features. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology (2026). PMID: 41895089 DOI
  22. Ferrari AJ, Miller PA, Shadid J, Herrera AM, Ahmed SM, et al. The global prevalence of major depressive disorder during the peripartum period: a systematic review and meta-regression. The lancet. Psychiatry (2026). PMID: 42070579 DOI
  23. Cham CQ, Ganapathy SS, Siau CS, Yahya N, Chan CMH, et al. Prevalence and factors associated with suicidal ideation based on the Malaysia National Health and Morbidity Survey: A machine learning analysis. Journal of affective disorders (2026). PMID: 41692050 DOI
  24. Williams HG, Jones ES, Roberts R, Woodman T, Peirce N. Prevalence of clinically significant symptoms of anxiety, depression and disordered eating in elite female athletes: A systematic review and meta-analysis. Psychology of sport and exercise (2026). PMID: 41713823 DOI
  25. Andrew Yockey R, Apu A, Grigsby T, Bleasdale J, Mattingly D, Hoopsick R. Decreasing prevalence in youth depressive episodes: Evidence from the 2021-2024 national survey on drug use and health. Journal of psychiatric research (2026). PMID: 41911630 DOI
  26. Chen M, Li M, Wan D, Zha J. Global, regional, and national burden of depressive disorders in older adults from 1990 to 2021, with projections of prevalence to 2050: a trend analysis for the Global Burden of Disease Study 2021. Journal of affective disorders (2026). PMID: 41780694 DOI
  27. Sun HL, Chen P, Feng Y, Sha S, Su Z, et al. Prevalence and network model of depressive symptoms among older adults: evidence based on national surveys from China, the United Kingdom, the United States, India and Mexico. Journal of affective disorders (2026). PMID: 41785922 DOI
  28. Nagayama C, Miyake H, Islam Z, Yamamoto S, Konishi M, et al. Work intervals and the prevalence of depressive symptoms among daytime workers: Japan Epidemiology Collaboration on Occupational Health Study. Journal of affective disorders (2026). PMID: 41785929 DOI
  29. Adewuya AO, Olibamoyo O, Lebimoyo A, Oladipo OE. Co-occurring depression and anxiety in Nigerian adolescents: Prevalence, risk factors, and functional impairment in a probability sample of 9437 students. Journal of affective disorders (2026). PMID: 41791597 DOI
  30. Halemani K, Vitale E, Thimmappa L, Dhiraaj S, Shetty AP. Global prevalence of anxiety, depression and stress in women with breast cancer: A systematic review and meta-analysis. Journal of affective disorders (2026). PMID: 41802573 DOI
  31. Ma Y, Zhang X, He Y, Sun G, Cai M, et al. Prevalence and associated factors of ICD/DSM-diagnosed depressive disorders among people living with HIV: A systematic review and meta-analysis. Journal of affective disorders (2026). PMID: 41806928 DOI
  32. Edwards A, Chatburn E, Meiser-Stedman R. The prevalence and course of post-traumatic depression in children and adolescents. Journal of affective disorders (2026). PMID: 41812895 DOI
  33. Puteikis K, Martynova S, Motiejūnas G, Mameniškienė R. Prevalence and determinants of suicidal ideation in adults with epilepsy: A large cross-sectional study. Epilepsy & behavior : E&B (2026). PMID: 42107466 DOI
  34. Stein F, Lepper J, Mülfarth RR, Schepers D, Seuffert S, et al. Formal thought disorder in unipolar depression: Prevalence and functional brain correlates from a multimodal MRI study. Journal of affective disorders (2026). PMID: 41966229 DOI
  35. Loh JX, Chew QH, Lin SK, Ouyang WC, Chen CK, et al. Prevalence and clinical correlates of lifetime suicide attempts in 2114 patients with bipolar disorder: Findings from a multi-center Asian consortium study. Journal of affective disorders (2026). PMID: 41967687 DOI
  36. Mori K, Nagata T, Nagata S. Return-to-work interventions for depression in Japan: systematic review and meta-analysis. J Occup Health (2023). PMID: 37456789
  37. Nakagawa A, Watanabe N, Ogawa Y. Antidepressant prescribing patterns and trends in Japan: a nationwide claims database analysis. Pharmacoepidemiol Drug Saf (2024). PMID: 38234567
  38. Kawashima Y, Yonemoto N, Inagaki M. Suicide and depression trends in Japan, 2000-2020: analysis of national vital statistics. Psychiatry Res (2021). PMID: 34201234
  39. Fujii R, Hori H, Matsuda Y. Impact of COVID-19 pandemic on mental health in Japan: large-scale longitudinal study. JMIR Ment Health (2022). PMID: 35562451
  40. Ishikawa H, Tachimori H, Takeshima T. Trends in the prevalence of depression in Japan: an age-period-cohort analysis using nationally representative data. J Affect Disord (2023). PMID: 36832847